Wellbutrin SR

Generic Name: Bupropion HCL (byoo-PROE-pee-on)

Drug Class: Antidepressant, Miscellaneous


Drug Uses

This medicine is classified as an antidepressant used to treat depression. Your doctor may prescribe this medicine for other conditions such as quitting smoking.

General Information

Ginseng, ma huang, yohimbine and St. John's Wort may interact with antidepressants. Talk to your healthcare provider before combining medicines with herbs.

How it Works

Bupropion increases the amount of two chemicals in the brain, norephineprine and dopamine.

How to Take It

Follow the directions given to you by your doctor. Swallow the tablet whole. Do not crush or chew before swallowing. This medicine is taken orally and may be taken with food if stomach upset occurs. Take this medicine regularly at the same time every day.

Possible Side Effects

    • dizziness, drowsiness
    • headache
    • nausea, vomiting
    • restlessness, agitation
    • constipation


    • This medicine may cause dizziness or drowsiness.

    • Do NOT drive or perform other hazardous tasks until you know how this medicine affects you.

    • Do NOT take this medicine if you are allergic to it or any of its ingredients.

    • It may take several weeks before you start feeling better.

    • Do NOT abruptly stop this medicine without talking to your doctor.

    • Inform your doctor if you have a history of seizures.


    • Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

    • Do not take MAO inhibitors type A with this medicine. If you are not sure if you are taking an MAO inhibitor, talk to your doctor or pharmacist. Certain other antidepressants, clozapine (Clozaril), haloperidol (Haldol), lithium, trazadone, and others may increase the risk of seizures. BEFORE taking any new prescription or over-the-counter medicine, talk to your health care provider.

Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


For women: Adequate studies of pregnant women are not available. If you plan on becoming pregnant, talk to your doctor about the benefits versus the risks of using this medicine during pregnancy. For nursing mothers, this medicine is excreted in breast milk in small amounts. Check with your doctor if you plan to nurse your baby.

More Information

For more information, talk to your doctor, pharmacist or health care provider.

Last reviewed: By John M. Grohol, Psy.D. on 19 May 2015
    Published on PsychCentral.com. All rights reserved.