Generic Name: lisdexamfetamine (lis dex am FET a meen)

Drug Class: CNS Stimulant


Drug Uses

This medicine is used in patients to treat attention deficit hyperactivity disorder (ADHD) in adults and in children (6 years old and older). It is a central nervous system (CNS) stimulant medication. Doctors may also prescribe this medicine for other conditions as well, such as moderate to severe binge eating disorder (BED) in adults.

General Information

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How to Take It

Follow the directions for using this medicine provided by your doctor. Vyvanse should be taken in the morning with or without food.

Do not take this medicine in the evening because it may cause sleep problems (insomnia).

Do not crush, chew, break, or divide a capsule. Swallow the capsule whole. To make swallowing easier, you may open the capsule and sprinkle the medicine into a glass of water or mix it with yogurt. After the medicine has dissolved, drink or eat the mixture immediately. Do not save for later use. Take this medicine regularly, do not skip doses.

Possible Side Effects

Side effects that this medicine may cause include:

  • dry mouth
  • loss of appetite
  • weight loss
  • sleep problems (insomnia);
  • dizziness, feeling irritable;
  • nausea, vomiting, stomach pain, diarrhea

If these side effects are bothersome check with your health care provider.

Check with your doctor as soon as possible if you experience any of the following:

  • chest pain, shortness of breath, fast or uneven heart rate;
  • confusion, paranoia, unusual thoughts or behavior, hallucinations;
  • unexplained muscle pain, tenderness, or weakness;
  • erection that is painful or lasts 4 hours or longer (rare); or
  • numbness, pain, cold feeling, unexplained wounds, or skin color changes (pale, red, or blue appearance) in your fingers or toes.

If you experience other bothersome side effects, contact your health care provider.


  • Do NOT stop taking this medicine without first checking with your doctor.

  • Before you have any medical or dental appointments or surgery, tell your doctor or dentist that you are taking this medicine.

  • This medicine can cause dizziness or drowsiness.

  • The side effects may affect your ability to operate a motor vehicle safely.


  • Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Tell your doctor if you have:

  • heart disease, heart rhythm disorder;
  • high blood pressure;
  • coronary artery disease (hardened arteries); or
  • history of heart attack.

To make sure this medicine is safe for you, tell your doctor if you have:

  • kidney disease;
  • circulation problems;
  • peripheral vascular disease such as Raynaud's syndrome;
  • a personal or family history of mental illness, psychotic disorder, bipolar illness, depression, or suicide attempt; or
  • if you take an antidepressant.

Before taking any new prescription or over-the-counter medicine, talk to your doctor or pharmacist. Other medicine can affect the way carbamazepine works in the body.

Do not take this medication if you have taken an MAOI inhibitor in the past 2 weeks.

Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. However, lisdexamfetamine may cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes Vyvanse during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Lisdexamfetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Vyvanse Dosing

Usual Adult Dose for Attention Deficit Disorder:

  • Initial dose: 30 mg orally once a day in the morning
    If necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg. Maintain patients on their optimal dose.

Usual Pediatric Dose for Attention Deficit Disorder:

  • 6 years or older:
    Initial dose: 30 mg orally once a day in the morning If necessary, the initial daily dose may be increased by 10 mg to 20 mg approximately once a week up to a maximum daily dose of 70 mg. Maintain patients on their optimal dose.

Vyvanse has not been studied in children under 6 years of age. Long-term effects of amphetamines in children have not been well established. Amphetamines are not recommended for use in children under 3 years of age.

More Information

For more information, talk to your doctor, pharmacist or health care provider.

Last reviewed: By John M. Grohol, Psy.D. on 30 Jun 2015
    Published on PsychCentral.com. All rights reserved.