Generic Name: Nefazodone (na-FAZ-oh-dohn)

Drug Class: Antidepressant


Drug Uses

This medicine is used for depression. Your doctor may prescribe this medicine for other conditions as well.

General Information

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How it Works

This drug works by increasing a chemical called 5-HT by blocking its reuptake. It also blocks the 5-HT2 receptor.

How to Take It

Follow the directions that your doctor has given you. This medicine can be taken with food to avoid stomach upset. It may take up to 4 weeks before this medicine reaches its full effect.

Possible Side Effects

    • dizziness, drowsiness
    • agitation, confusion
    • constipation
    • dry mouth
    • Consult your doctor immediately if you experience prolonged and painful erections.


    • Do NOT stop taking this medicine abruptly.

    • Do NOT drink alcohol with this medicine.

    • Alcohol and other depressants can increase the side effects when taking with this medicine.

    • This medicine may cause dizziness or drowsiness.

    • Do NOT drive or perform other tasks requiring your full attention, until you know how this medicine affects you.

    • If you have a history of seizures, or heart disease, let your doctor know.


    • Seek medical attention immediately. For non emergencies, contact your local or regional poison control center.

Drug Interactions

    • Nafazodone can decrease the effects of clonidine, methyldopa, diuretics (water pills), warfarin and drugs used to lower blood sugar (hypoglycemics). This medicine can increase the toxic effects of; terfenadine, astemizole, fluoxetine (Prozac), triazolam, alprazolam (Xanax) and phenytoin (Dilantin). Do not take this medicine within 14 days of stopping MAO inhibitors. If you are not sure what an MAO inhibitor is, talk to your doctor or pharmacist. If you are currently taking any of these medicines, talk to your doctor or pharmacist to see if Nefazodone is right for you.

Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


If you are pregnant or planning a pregnancy, talk to your doctor. This medicine is not recommended during pregnancy unless the benefits clearly outweigh the risks to the fetus. It is unknown whether this medicine is excreted in breast milk. Talk to you doctor before you breast feed.

More Information

For more information, talk to your doctor, pharmacist or health care provider.

Last reviewed: By John M. Grohol, Psy.D. on 19 May 2015
    Published on All rights reserved.