Generic Name: methylphenidate (METH il FEN i date)

Drug Class: CNS Stimulant


Drug Uses

This medicine is used in patients to treat attention deficit hyperactivity disorder (ADHD) in adults and in children (6 years old and older). It is a central nervous system (CNS) stimulant medication. Doctors may also prescribe this medicine for other conditions as well.

General Information

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How to Take It

Follow the directions for using this medicine provided by your doctor.

The medicine comes with a dosing schedule that shows when to apply and remove a skin patch based on 9-hour time frames. Ask your doctor or pharmacist if you have any questions.

Open the sealed pouch and remove the protective liner. Apply to a clean and dry area on your hip. Press the Daytrana patch onto the skin with the palm of your hand for about 30 seconds. When properly applied, the patch should stay on while swimming or bathing.

Wash your hands after applying a Daytrana skin patch.

The effects of this medicine may not be noticeable until 2 hours after applying the skin patch. Remove the patch 9 hours after it was applied. Peel off slowly and fold the patch in half so it sticks together. Use baby oil or lotion to remove any adhesive residue that stays on your skin.

Flush the folded patch down the toilet or place it into a waste can with a lid.

Apply a new patch to the opposite hip. Do not wear a patch on the same side of the body two days in a row.

If a patch falls off, replace it with a new one. Then remove the new patch after it has been 9 hours since you applied the first patch. Do not wear a patch longer than 9 hours per day, even if you apply a new patch to replace one that has fallen off. Use the dosing schedule provided to track your patch wearing time.

If you have trouble sleeping or loss of appetite in the evenings, try removing the skin patch earlier in the day. Never cut the skin patch to try and reduce the amount of medicine you receive while wearing it.

Keep each patch in its sealed pouch until you are ready to use it. Store at room temperature away from heat and moisture. Throw away any unused patches if it has been more than 30 days since you opened the original package.

Do not cut or divide this medication. Take this medicine regularly, do not skip doses.

Possible Side Effects

Side effects that this medicine may cause include:

  • loss of appetite, weight loss;
  • sleep problems (insomnia);
  • dizziness, mood swings, feeling irritable;
  • nausea, vomiting, stomach pain, upset stomach;
  • mild skin irritation or redness, bumps where patch was worn.

If these side effects are bothersome check with your health care provider.

Check with your doctor as soon as possible if you experience any of the following:

  • new or worsening symptoms such as mood swings, aggression, hostility, or changes in personality or behavior;
  • paranoia, delusion, extreme fear, hallucinations, unusual behavior, motor tics (muscle twitches);
  • redness, swelling, or blistering where the skin patch was worn (may also spread to other areas);
  • vision problems;
  • chest pain, fast or slow heart rate, pounding heartbeats or fluttering in your chest, feeling like you might pass out;
  • numbness, pain, unexplained wounds, cold feeling, or skin color changes (pale, red, or blue appearance) in your fingers or toes;
  • erection that is painful or lasts 4 hours or longer (rare); or
  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, anxiety, confusion, chest pain, shortness of breath, uneven heartbeats, seizure).

If you experience other bothersome side effects, contact your health care provider.


  • Do NOT stop taking this medicine without first checking with your doctor.
  • Before you have any medical or dental appointments or surgery, tell your doctor or dentist that you are taking this medicine.
  • This medicine can cause dizziness or drowsiness.
  • The side effects may affect your ability to operate a motor vehicle safely.


  • Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

Tell your doctor if you have:

  • high blood pressure;
  • a history of mental illness or psychosis;
  • peripheral vascular disease such as Raynaud's syndrome;
  • epilepsy or other seizure disorder;
  • a history of drug or alcohol addiction.

You should not use this medication if you have:

  • glaucoma;
  • taken an MAOI inhibitor in the past 2 weeks;
  • a personal or family history of tics (muscle twitches) or Tourette's syndrome; or
  • severe anxiety, tension, or agitation (methylphenidate can make these symptoms worse).

Before taking any new prescription or over-the-counter medicine, talk to your doctor or pharmacist. Other medicine can affect the way carbamazepine works in the body.

Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


FDA pregnancy category C. It is not known whether this medication will harm an unborn baby. However, lisdexamfetamine may cause premature birth, low birth weight, or withdrawal symptoms in a newborn if the mother takes Vyvanse during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using this medication.

Lisdexamfetamine can pass into breast milk and may harm a nursing baby. Tell your doctor if you are breast-feeding a baby.

Daytrana Dosing

Usual Dose for Attention Deficit Disorder:

  • The medicine comes with a dosing schedule that shows when to apply and remove a skin patch based on 9-hour time frames. Keep the patch in the sealed pouch it comes in until ready to be applied. Do not apply patch to the same side of the body two days in a row.

More Information

For more information, talk to your doctor, pharmacist or health care provider.

Last reviewed: By John M. Grohol, Psy.D. on 30 Jun 2015
    Published on All rights reserved.