Generic Name: Amoxapine (a-MOX-a-peen)

Drug Class: Antidepressant, Tricyclic


Drug Uses

This medication is used to treat depression and for chronic neuropathic pain (nerve pain) or to prevent migraine headaches. Your doctor may prescribe this medicine for other conditions as well.

General Information

This information is for educational purposes only. Not every known side effect, adverse effect, or drug interaction is in this database. If you have questions about your medicines, talk to your health care provider.

How it Works

Helps depression by restoring two natural chemicals (serotonin and norephinephrine).

How to Take It

Amoxapine comes as a tablet to take by mouth. It is usually taken one or more times daily. It may be taken with or without food. Take this medicine as directed and do not take more or less of it or more often than prescribed by your doctor. Continue to take this medicine even if you are feeling better. Do not stop taking amoxapine without talking to your doctor, especially if you have taken large doses for a long time. Your doctor will probably will want to decrease your dose slowly.

Possible Side Effects

    • Some COMMON SIDE EFFECTS reported with this medicine include:

      • upset stomach
      • drowsiness
      • dizziness
      • dry mouth
      • weakness or tiredness
      • insomnia
      • nightmares
      • skin more sensitive to sunlight
      • constipation
      • nausea
      • blurred vision
      • headache
      • weight gain
    • An allergic reaction to this medicine is unlikely, but seek immediate medical attention if it occurs. Symptoms of an allergic reaction include rash, itching, swelling, severe dizziness, or trouble breathing.

    • If you experience any of the following symptoms, call your doctor immediately:

      • jaw; neck and back muscle spasms
      • slow or difficult speech
      • shuffling walk
      • fine tremor
      • fever
      • difficulty breathing or swallowing
      • severe skin rash
      • yellowing of the skin or eyes
      • irregular heartbeat


    • This medicine should NOT be used by those:

      • having taken MAO inhibitors in the last two weeks
      • with narrow angle glaucoma
      • with irregular heart beat
    • Elderly patients generally should avoid it because of an increase in dizziness and falls.

    • This medicine may cause dizziness or drowsiness. Alcoholic beverages can increase the side effects of this medicine and should be avoided.


    • Seek medical attention immediately. For non emergencies, contact your local or regional poison control center at 1-800-222-1222.

Drug Interactions

    • Possible drug interactions may occur with amitriptyline and:

      • Phenobarbital
      • MAO inhibitors (severe)

    • Tell your doctor and pharmacist what prescription and nonprescription drugs you are taking or have taken within the last 2 weeks, especially:

      • anticoagulants (Warfarin)
      • cimetidine (Tagamet)
      • estrogens
      • fluoxetine (Prozac)
      • levodopa (Sinemet)
      • lithium (Eskalith; Lithobid)
      • MAO inhibitors (phenelzine; tranylcypromine)
      • blood pressure medications
      • seizure medicine
      • medicine for Parkinson's disease
      • asthma medications
      • cold/allergy medications
      • methylphenidate (Ritalin)
      • muscle relaxants
      • birth-control pills
      • sedatives
      • sleep medicines
      • thyroid medicines
      • tranquilizers
      • vitamins and herbal remedies

Missed Dose

Take your next dose as soon as you remember. If it is time for your next dose, skip the missed dose and go back to your regular schedule. Do not double doses.


Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture (not in the bathroom). Throw away any medication that is outdated or no longer needed.


For women, it should be avoided during pregnancy and nursing. As with other medications, if you suspect that you may be pregnant, talk to you physician or pharmacist before using this medication.

More Information

This medicine may cause depletion of Coenzyme Q10 and vitamin B2. Talk to your doctor about adding these supplements to your diet.

Last reviewed: By John M. Grohol, Psy.D. on 19 May 2015
    Published on All rights reserved.